Xeloda is used to treat: cancer of the colon or rectum that has spread to other parts of the body (metastatic colorectal cancer) when fluoropyrimidine therapy alone is preferred. Patients and physicians should note that combination chemotherapy has shown a survival benefit compared to 5-fluorouracil (5-FU)/oral leucovorin ( LV ) alone. A survival benefit over 5-FU/LV has not been demonstrated with Xeloda monotherapy. Dukes’ C colon cancer in patients who have had complete removal of the tumor when treatment with fluoropyrimidine therapy alone is preferred.
Although neither Xeloda nor combination therapy prolongs overall survival, combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone. breast cancer that has spread to other parts of the body and has not responded to treatment with certain other medicines. These medicines include paclitaxel (Taxol) and anthracycline-containing therapy such as Adriamycin and doxorubicin.
Xeloda is changed in the body to the substance 5-fluorouracil. In some patients with colon, rectum or breast cancer, this substance stops cancer cells from growing and decreases the size of the tumor. Who should not take Xeloda? You should not take Xeloda if you are allergic to 5-fluorouracil (5-FU) because Xeloda is converted by the body to 5-FU. You should not take Xeloda if you have severe renal impairment. You should not take Xeloda if you are nursing a baby. Xeloda may pass into the milk and harm the baby.
Special Warnings Concerning Xeloda: Xeloda can cause diarrhea, which may be severe. If you have more than 4 bowel movements a day, or diarrhea at night, stop taking Xeloda and contact your doctor. Patients over 80 may have more gastrointestinal side effects such as diarrhea, nausea, and vomiting. Xeloda may cause harm to your unborn child. Do not become pregnant while taking Xeloda. Women should use effective birth control. Men should also practice birth control measures while taking Xeloda. Tell your doctor if you are taking a drug that affects blood clotting such as Coumadin or warfarin. After Xeloda became available, there have been reports to the FDA of changes in blood clotting and/or bleeding in people taking Xeloda together with certain anticoagulants (blood thinners). See your doctor regularly for monitoring.