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International Name :
Avapro 150
Active Ingredient :
Irbersartan 150mg
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AVAPRO* (irbesartan) is an angiotensin II receptor (AT1 subtype) antagonist.

Irbesartan is a non-peptide compound, chemically described as a 2-butyl-3-[p-(o-1H-tetrazol-5-ylphenyl) benzyl]-1,3-diazaspiro[4,4]non-1-en-4-one.

Its empirical formula is C25H28N6O,and the structural formula:

Irbesartan is a white to off-white crystalline powder with a molecular weight of 428.5.It is a nonpolar compound with a partition coefficient (octanol/water) of 10.1 at pH of 7.4. Irbesartan is slightly soluble in alcohol and methylene chloride and practically insoluble in water.

AVAPRO is available for oral administration in unscored tablets containing 75 mg,150 mg,or 300 mg of irbesartan. Inactive ingredients include: lactose, microcrystalline cellulose, pregela-tinized starch, croscarmellose sodium, poloxamer 188,silicon dioxide and magnesium stearate.

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