- Velasof is an composition of Velpatasvir ( 100mg ) and Sofosbuvir ( 400mg ). Velasof contains two drug combination which is used for the treatment of hepatitis C. It is administered as a single daily pill containing the viral NS5A inhibitor Velpatasvir and Sofosbuvir,a nucleotide inhibitor of the viral RNA polymerase. It is the first treatment, that works for all type of genotypic, and it is taken completely by mouth i.e. oral dose. A single tablet regimen is used for adults with genotype 1-6 chronic hepatitis C virus (HCV) infection with pangenotypic activity. In packaging , there are total 28 tablets in each bottle. Each tablet contains 400 mg Velpatasvir and 100 mg Sofosbuvir. Brand name is Velasof . The composition of Velasof is Velpatasvir & Sofosbuvir . Manufacturer of Velasof is Hetero. Strength of one velasof tablet is Velpatasvir 100Mg & Sofosbuvir 400Mg. The composition of sofosbuvir + velpatasvir medication used to treat Chronic hepatitis C infection in adults.
Mechanism of action:
Velasof is a fixed dose combination of sofosbuvir + velpatasvir, a nucleotide analog NS5B polymerase inhibitor and velapatasvir, an NS5A replication complex inhibitor. Sofosbuvir is currently approved in the treatment of genotype 1, 2, 3 and 4 HCV infection with different regimens and durations dependent on the HCV genotype. At the picomolar level, Velpatasvir is a novel NS5A inhibitor that has potent in vitro anti-HCV activity across all genotypes.. The combination of sofosbuvir-velpatasvir is the first once-daily single-tablet regimen with pangenotypic activity.
Dosage and Administration:
Take Velasof tablet as your healthcare provider tells you to,
- In case of cirrhosis , patients with compensated cirrhosis or without cirrhosis (Child-Pugh A): Take velasof tablet for 12 weeks.
- In case of decompensated cirrhosis , Patients with decompensated cirrhosis (Child-Pugh B or C): velasof
- There is Weight-based ribavirin dose.
- If your weight is less than 75 kg: 1000 mg/day PO divided BID
- If your weight is Greater than or equal to 75 kg (≥75 kg): 1200 mg/day
- Ribavirin starting dose and on-treatment dosage should be take based on hemoglobin and creatinine clearance
- Warning :
Velasof medicine keep out of the reach. Keep out from sight of children and away from pets, you never share your medicines with others, and use this medication only if doctor prescribed it .