PRIGILY -30 MG Dapoxetine hydrochloride-30 mg
Dapoxetine hydrochloride & premature ejaculation ( INTERNATIONAL NAME: PRIGILY)
What is premature ejaculation ?
Premature ejaculation is the most common male sexual dysfunction, affecting as many as one-third of male population worldwide at some time in their lives.
An occasional instance of PE might not be cause for concern, but if the problem occurs with more than 50% of attempted sexual relations, then a dysfunctional pattern usually exists for which treatment may be appropriate.
Professor Alan White, professor of men’s health at Leeds Metropolitan University and chairman of the Men’s Health Forum, said: “”This ( PREMATURE EJECULATION) is certainly a problem that affects many men – as many as one in three or four.
“”It’s one of those hidden conditions that can cause terrible problems in a relationship and a great deal of embarrassment. “”Men are often reluctant to discuss it with their doctor and if a medication became available, it might make them more willing to go and discuss the problem with their doctor.
What causes it?
Though it is quite common in men, the exact cause of Premature Ejaculation is still unclear. Experience and Psychological factors have been primarily related as contributors to this condition. The duration of time for ejaculation is not the true concern during the intercourse but the issue is whether the couple is really satisfied with the activity or not.
What is Dapoxetine ?
Dapoxetine is chemically similar to a family of antidepressants called SSRIs (selective serotonin reuptake inhibitors).
It’s one of those hidden conditions that can cause terrible problems in a relationship and a great deal of embarrassment
Professor Alan White, chairman of the Men’s Health Forum
These types of antidepressants are known to have an impact on ejaculation.
Trials of dapoxetine have included 2,614 men aged 18-77 with premature ejaculation, who maintained monogamous sexual relationships for more than six months.
Each received 30mg or 60mg of dapoxetine or a dummy pill over 12 weeks.
Dapoxetine trebled the duration of intercourse. This beneficial effect occurred after the first dose and increased over the study period.
Dapoxetine online treatment for premature ejaculation
Dapoxetine hydrochloride, the new cure for premature ejaculation (PE) could become Viagra Reloaded for male population. Dapoxetine hydrochloride data clearly indicates that men taking dapoxetine for the treatment of PE experienced significant improvements in sexual function, as well as in ejaculatory control, satisfaction with sexual intercourse for men and their partners, and increases in IELT (intravaginal ejaculatory latency time). These data collection were presented at the 100th Annual Scientific Meeting of the AUA (American Urological Association).
If Viagra has made sex possible for men suffering from impotence, this new drug aims to regulate premature problems and to make it last longer. Much longer…
Dapoxetine: A new drug to treat premature ejaculation
In 2005 the National Horizon Scanning Centre, University of Birmingham, prepared a briefing report on dapoxetine hydrochloride for premature ejaculation in which discusses the drug’s mechanism of action:
Dapoxetine hydrochloride (AP 38) – Janssen-Cilag, is a SSRI in development for the management of premature ejaculation. Its mechanism of action is to increase the level of serotonin in the central nervous system. An observed, and usually adverse, effect of SSRIs is a delay in ejaculatory latency time although the precise mechanism of action is unknown. Dapoxetine has a rapid onset of action of approximately 1.5 hours and a short half-life and the company anticipate a dose of 30 or 60mg 1-3 hours before intercourse not to be taken more frequently than once every 24 hours. On the 9th of September 2006, the Lancet published the results of two double-blind trials of dapoxetine which found the SSRI improved intravaginal ejaculatory latency time compared to placebo. Concerning how the drug might work, the authorÕs ÊPryor et al suggest:
The underlying pathophysiology of premature ejaculation is not completely understood, although both physiological and psychological components could contribute to the condition. Psychopharmacological studies suggest that premature ejaculation might be related to diminished serotonergic neurotransmission through pathways that control ejaculation. Dapoxetine is a short acting SSRI developed specifically for the treatment of premature ejaculation. The drug’s mechanism of action is thought to be related to inhibition of neuronal reuptake of serotonin and subsequent potentiation of serotonin activity. By contrast with SSRIs approved for depression, which take 2 weeks or longer to reach steady-state concentration, dapoxetine has a unique pharmacokinetic profile, with a short time to maximum serum concentration (about 1 h) and rapid elimination (initial half-life of 1-2 h). By 24 h, plasma concentrations are less than 5% of peak values. These attributes make dapoxetine suitable for on-demand therapy. 
National Horizon Scanning Centre. Dapoxetine hydrochloride for premature ejaculation. January 2005. (http://www.pcpoh.bham.ac.uk/publichealth/horizon/PDF_files/2005reports/Dapoxetine.pdf ). Pryor JL, Althof SE, Steidle C et al for the Dapoxetine Study Group. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials. The Lancet – Vol. 368, Issue 9539, 09 September 2006, Pages 929-937.