KIWOF PLUS, Praziquantel, Pyrantel Pamoate and Febantel Tablets
Kiwof – Plus Tablets contain three active ingredients having different modes of action and spectra of activity. Praziquantel is active against cestodes (tapeworms). Praziquantel is absorbed, metabolized in the liver and excreted in the bile. Upon entering the digestive tract from the bile, cestocidal activity is exhibited. Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolices, are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool. The majorities of tapeworms are digested and are not found in the feces.
Pyrantel Pamoate is active against hookworms and ascarids. Pyrantel Pamoate acts on the cholinergic receptors of the nematode resulting in spastic paralysis. Peristaltic action of the intestinal tract then eliminates the parasite.
Febantel is active against nematode parasites including whipworms. Febantel is rapidly absorbed and metabolized in the animal.
Available information suggests that the parasite’s energy metabolism is blocked, leading to energy exchange breakdown and inhibited glucose uptake.
Kiwof – Plus Tablets are indicated for removal of Tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus and removal and control of Echincoccus multilocularis). For removal of Hookworms (Ancylostoma caninum, Uncinaria stenocephala), Ascarids (Toxocara canis, Toxascaris leonina) and Whipworms (Trichuris vulpis) in dogs.
DOSAGE AND ADMINISTRATION:
For oral administration only.
The tablets can be given directly to the dog or disguised in food. No starvation is needed before or after treatment.
– For routine control adult dogs should be treated every 3 months. For routine treatment a single dose is recommended. In the event of heavy roundworm infestation a repeat dose should be given after 14 days.
The recommended dose rates are: 15 mg/kg bodyweight Febantel, 14.4 mg/kg Pyrantel and 5 mg/kg praziquantel. This is equivalent to 1 tablet per 10 kg bodyweight.
Kiwof —Plus Dosage Guide: Small dogs
Over 3 kg up to 5 kg bodyweigh = 1/2 Kiwof — Plus Tablet Over 5kg up to 10 kg bodyweight = 1 Kiwof – Plus Tablet
Kiwof —plus Dosage Guide: Medium Dogs
Over 10kg up to 15 kg bodyweight = 1 1/2 Kiwof – Plus Tablet
Over 15 kg up to 20 kg bodyweight = 2 Kiwof — Plus Tablet over 20 kg up to 25 kg bodyweight = 2 1/2 Kiwof – Plus Tablet
Over 25 kg up to 30 kg bodyweight= 3 Ki w of — Plus Tablet
Kiwof —plus Dosage Guide: Large Dogs
Over 30 kg up to 35 kg bodyweight = 3 1/2 Kiwof – Plus Tablet
Over 35 kg up to 40 kg bodyweight = 4 Kiwof — Plus Tablet
For routine treatment a single dose is recommended.
PREGNANCY AND LACTATION:
– Consult a veterinary surgeon before treating pregnant animals for roundworms.
– The product may be used during lactation.
– Do not exceed recommended dose when treating pregnant bitches.
CONTRA-INDICATIONS, WARNINGS, ETC:
Do not use simultaneously with piperazine compounds.
In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog s food, should wash their hands afterwards.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Strict hygienic precautions should be taken when handling dogs or feces suspected of harboring E. multilocularis. Infected dogs treated for the first time with KiwofTM plus Tablets and dogs treated at intervals greater than 28 days may shed eggs in the feces after treatment. The animal should be held in the clinic during this interval and all feces should be incinerated or autoclaved. If these procedures are not possible, the eggs can be destroyed by soaking the feces in a sodium hypochlorite (bleach) solution of 3.75% or greater. All areas where the animal was maintained or in contact with should be thoroughly cleaned with sodium hypochlorite and allowed to dry completely before reuse.
KiwofTM Plus should be used alone and never combined with other de-worming medicine.
ADVERSE DRUG REACTIONS:
None reported. Vomiting was reported in some cases.