Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. In the intestine, an enzyme called lipase (produced primarily by the pancreas) breaks apart fat in food so that it can be absorbed into the body. Orlistat blocks the action of lipase and thereby prevents the breakup and absorption of fat. Orlistat blocks absorption of about 25% of the fat in a meal. The unabsorbed fat is excreted in the stool. The FDA approved Orlistat by prescription in 1999. alli, a lower dose formulation of orlistat, was approved for purchase without a prescription “”over the counter”” in 2007.
PREPARATIONS: Capsules: 60 mg (alli), 120 mg (Xenical), SLIM TRIM ACTIVE-60MG
STORAGE: Capsules should be stored at room temperature, 15-30 C (59-86 F)
PRESCRIBED FOR: Orlistat is combined with a reduced-calorie diet to promote weight loss. Orlistat also may be used to prevent weight gain after weight has been lost. Candidates for treatment with orlistat are patients who are obese with a body mass index (a measure of obesity) of more than 30 kg/m2. Candidates also include patients with a body mass index of between 27 and 30 kg/m2 if other risk factors for arteriosclerosis are present such ashigh blood pressure, diabetes, and elevated blood cholesterol or triglycerides. Based on several scientific studies, the average weight loss that is achieved when orlistat is taken as recommended for six months to one year is 12.4 to 13.4 pounds.
DOSING: The recommended prescription dose for Xenical is one capsule (120 mg) three times daily.
The recommended dose for alli is 60 mg three times daily. Orlistat should be taken one hour after or during a meal containing about 15 mg of fat. Meals without fat do not require orlistat. No additional benefit has been shown when orlistat was taken in doses greater than 120 mg. Patients should eat a nutritionally balanced, reduced calorie diet that contains approximately 30% of calories from fat. alli includes an individually tailored online weight loss support program.